NAD+
Recharge every cell, reclaim your energy
About NAD+
NAD+ (nicotinamide adenine dinucleotide) is a coenzyme found in every cell of your body. It is essential for producing energy in the mitochondria, supporting DNA repair, and powering the enzymes that regulate metabolism and stress response. NAD+ levels decline with age, which has made it a focus of longevity and energy research. At PreventiveMD it is offered as a subcutaneous injection that you self-administer at home as part of a broader wellness plan.
Common reasons patients ask about NAD+:
- May support sustained energy and reduced fatigue
- Studied for its role in mitochondrial function and metabolic recovery
- May support mental clarity and focus in some patients
- Often used as part of a broader longevity or recovery routine
Data
What the studies show
NAD+ has been studied for decades in basic science and is an active area of research in aging, metabolism, and neurodegeneration. Most published clinical work on NAD+ supplementation in humans comes from small studies or trials of precursors (NR, NMN) rather than NAD+ itself; large randomized trials of NAD+ administration in healthy adults are limited. It is best framed as a promising but evolving area of research.
~50%
Estimated decline in NAD+ levels between young adulthood and midlife in some studies
Active
Area of clinical and longevity research
Emerging
Evidence in humans — most trials are small or use precursors
How it works
Powers mitochondrial energy and DNA repair
NAD+ is a cofactor in the reactions that convert nutrients into ATP, the energy your cells run on. It also activates sirtuins and PARPs — enzyme families involved in DNA repair, gene regulation, and stress response. When NAD+ levels are higher, these systems have more raw material to work with; when they fall, downstream processes slow.
Eligibility
Who NAD+ is for
Generally a good fit for
- Adults experiencing fatigue, brain fog, or recovery slowdown
- Patients pursuing a structured longevity or wellness plan
- People interested in supporting energy and cellular health as they age
Not appropriate for
- Pregnancy, planning pregnancy, or breastfeeding without provider guidance
- Active cancer or undergoing chemotherapy without oncology input — NAD+ research in cancer is mixed
- Severe cardiovascular disease without provider clearance
- Known hypersensitivity to NAD+ preparations
See how NAD+ levels change with age
NAD+ naturally declines over time. Enter your age to see where your projected level sits relative to peak (around age 20).
Projected NAD+ level
—
Age
Educational illustration based on cited population averages — not a measurement of your individual NAD+ status. Real levels vary with sleep, stress, exercise, and other factors.
Journey
What to expect & when
Weeks 1–4
- Some patients report improved energy, sleep, or mental clarity early on
- Effects are subjective and vary by person
Weeks 5+
- Continued benefit for some patients with ongoing protocols
- Often used as part of a maintenance plan rather than a one-time treatment
Ongoing
- Continued monitoring, dose adjustments, and cycling decisions guided by your PreventiveMD provider
Side effects
Safety & side effects
NAD+ subcutaneous injections are generally well tolerated. Most side effects are mild and tend to be most noticeable in the first few doses as your body adjusts.
Common
- Flushing or warmth shortly after injection
- Nausea or stomach discomfort
- Headache
- Injection-site soreness or redness
Less common but serious
- Allergic reaction
- Persistent cardiovascular symptoms — chest pressure, palpitations, or dizziness that don't resolve
- Interactions with other supplements or medications — disclose your full list to your provider
If you have questions about whether NAD+ is right for you, your PreventiveMD provider will review your full health history once you get started.
Dosing
How to take NAD+
NAD+ subcutaneous injections are typically given several times per week. Specific dose is set by your provider based on goals and tolerance.
How to inject
- 1Wash your hands thoroughly.
- 2Choose an injection site your provider recommended, rotating to a different spot than your last injection.
- 3Clean the site with an alcohol wipe and let it dry completely, then inject as instructed.
- 4Place the used needle and syringe in your sharps container.
Seek emergency care immediately if you experience difficulty breathing or swallowing, swelling of the face, lips, tongue, or throat, hives or a widespread rash, dizziness or fainting, or a rapid heartbeat. These can be signs of a serious allergic reaction.
Pricing
Transparent pricing, no surprises
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FAQs
In case you were wondering
NR (nicotinamide riboside) and NMN (nicotinamide mononucleotide) are precursors — your body converts them into NAD+. Direct NAD+ injection bypasses that conversion step. Each approach has different research strengths and limitations.
Some patients notice flushing, warmth, or a brief head-rush sensation shortly after an NAD+ injection — particularly early in a protocol. This typically eases on its own as your body adjusts. Let your provider know if it persists or feels intense.
Some patients report changes within days of a series of treatments. Others see gradual improvement over weeks. NAD+ is best framed as part of a long-term plan, not a one-time fix.
Compounded NAD+ used in wellness clinics is not FDA-approved as a finished drug product. It is prepared under physician supervision for individual patients. This is a different regulatory pathway than retail prescription drugs.
Our content is reviewed by our medical team and draws from peer-reviewed clinical research, FDA prescribing information, and recognized clinical guidelines. The primary sources cited on this page:
- [TODO: Pivotal clinical trial citation for NAD+]
[TODO: Authors, journal, year (DOI when available)]
- [TODO: Mechanism of action / review article]
[TODO: Authors, journal, year (DOI when available)]
- [TODO: FDA prescribing information / regulatory source]
- [TODO: Clinical society guideline or consensus statement]
How to get started
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